During Tube, the dome seemed to fill with soap bubbles which reflected the venue and drifted in front of a nebula of changing colors. During Pillow Jets, the view became that of a grassy path through a grove of trees under a starlit sky. Travelling down the path as the jam progressed, the grass and trees became tinged with glowing, multi-colored light, which periodically intensified and erupted from the ground through the branches, creating a firework effect. Mike and Trey teased Manteca during Steam. During Mountains in the Mist, the dome made it appear as if the venue was nestled in an evergreen-covered mountain range, with mist shrouding the sky from view. During Taste, the entire dome appeared to become covered in turning rings of Jim Pollock illustrations from the covers of the Live Phish CD releases, rendered in gold and black. During Sigma Oasis, the dome became a cloudscape, with trees, birds and sea creatures made out of bubbling clouds. During Fuego, a spotlight was used to create a silhouette of the band, with the image then recreated across the dome with effects added to make the band appear as flaming shadow people. During Twist, the dome became filled with multicolored letters tumbling before a backdrop of pulsing red circles. I Am Hydrogen was performed in a show without Mike's Song and Weekapaug Groove for the first time since October 31, 1987 (2,024 shows). A Life Beyond The Dream featured Trey on acoustic guitar. During Tweezer Reprise, the dome again displayed images of cars, this time tumbling into the distance. This show was connected to the other three with each night's setlist tied into a state of matter. This performance's matter type was gas.

This was the rescheduled date for the show that had been postponed due to the Omicron variant of COVID-19 surge in New York City in December of 2021. Moma Dance was unfinished. Page teased Long Tall Glasses in Gumbo.

Suzy contained Sunshine of Your Love teases by Page and Trey. Trey also teased Rhythm-A-Ning and The Tra La La Song (One Banana, Two Banana) in Magilla and sang some of the verses of Fee through a megaphone. Over the Rainbow was played for the first time since August 17, 1992 (160 shows). YEM and Rainbow featured Dave Matthews, LeRoi Moore, Boyd Tinsley, Carter Beauford, and Stefan Lessard from Dave Matthews Band. YEM also featured Fish on vacuum. Matthews was Trey’s substitute trampoline jumper during YEM. The opening act was Dave Matthews Band.

The Bowie intro contained Lawn Boy teases from Trey as well as Simpsons and All Fall Down signals. Trey teased Dazed and Confused in Big Ball Jam. The beginning of My Friend featured Trey on acoustic guitar. YEM contained Speed Racer and Mission: Impossible theme teases from Page. Immigrant Song was teased in the YEM vocal jam. Whipping Post featured Fish on vocals. Amazing Grace was performed without microphones.

Trey teased Have Yourself a Merry Little Christmas in Reba. Fish led the band in the debut of Setting Sail, which arose out of the vocal jam of YEM. Tweezer contained In-A-Gadda-Da-Vida teases from Page.

'A' Train contained a brief Sailor's Hornpipe tease from Trey, Possum included a Rhapsody in Blue tease from Page, and Caravan contained an Entrance of the Gladiators tease from Trey. Ya Mar contained "Napkin Pa" lyrics.

Humphries House had been a Zeta Upsilon ("Zu") frat house and monthly parties used to occur there that were referred to as "Full Moon at the Zoo" parties. A fire alarm sounded as Fluffhead moved into the Clod segment of Fluff’s Travels, which caused the building to be evacuated. When the band retook the stage, they started up a humorous pass at You Shook Me All Night Long and then dove back into Fluff’s Travels. Fire was dedicated to the “brave men” who turned off the fire alarm. Suzy contained Sailor's Hornpipe teases from Trey. Trey and Page teased Blue Monk in Possum. Bowie included a brief Frosty the Snowman jam in the intro, as well as a Riders on the Storm tease from Page and a Santa Claus is Coming to Town tease. Melt contained a Fish drum solo. Love You was played for the first time since October 31, 1987 (138 shows) and featured Fish on trombone. Harpua contained "Charge!" and Price of Love teases from Page, multiple Gimme Some Lovin' teases, and a Walk This Way tease from Mike.