Soundcheck: Nothing, Let Me Lie, Friday, Walls of the Cave (Unconfirmed)
Set 1: After Midnight, SlothThe Sloth, AlumniAlumni Blues > LTJPLetter to Jimmy Page > AlumniAlumni Blues[1], Mellow Mood, Access Me, Llama, All of These Dreams, Curtain WithThe Curtain With > SOAMuleScent of a Mule, ASIHTOSA Song I Heard the Ocean Sing, It's Ice > WotCWalls of the Cave
Set 2: Possum > Light > Mike'sMike's Song > Simple[2] > MakisupaMakisupa Policeman[3] -> Night Nurse[4] -> MakisupaMakisupa Policeman > WedgeThe Wedge, Ghost -> MangoThe Mango Song[5] > WeekapaugWeekapaug Groove[6] -> Llama Reprise
Encore: Show of Life
Performers: Trey Anastasio, Page McConnell, Jon Fishman, Mike Gordon
Notes: After Midnight was played for the first time since December 31, 1999 (206 shows). In Alumni, Trey added "from Goddard College" after the final "'cause I got a degree" lyric. Simple contained a Magilla tease from Page. Makisupa included the lyrics "Woke up this morning with a policeman at my door all I could do was shrug, and go back in my bedroom and smoke another nug." This show featured the Phish debut of Night Nurse; original artist Gregory Isaacs passed away the night before, October 25, 2010. Weekapaug was heavily teased by Trey in Mango before the segue into Weekapaug itself. Weekapaug subsequently contained a Can't You Hear Me Knocking jam, which featured lyrics from Ghost and Night Nurse, and was unfinished.
This show was part of the "2010 Fall Tour."